Molecular signaling in cancer stem cells of tongue squamous cell carcinoma: Therapeutic implications and challenges.

ABSTRACT: Head and neck squamous cell carcinoma is the seventh most common cancer worldwide with high mortality rates. Amongst oral cavity cancers, tongue carcinoma is a very common and aggressive oral cavity carcinoma. Despite the implementation of a multimodality treatment regime including surgical intervention, chemo-radiation as well as targeted therapy, tongue carcinoma shows a poor overall 5-year survival pattern, which is attributed to therapy resistance and recurrence of the disease. The presence of a rare population, i.e., cancer stem cells (CSCs) within the tumor, are involved in therapy resistance, recurrence, and distant metastasis that results in poor survival patterns. Therapeutic agents targeting CSCs have been in clinical trials, although they are unable to reach into therapy

SUBMITTER: Joshi P 

PROVIDER: S-EPMC10277967 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature