Pipeline for transferring annotations between proteins beyond globular domains.

ABSTRACT: DisProt is the primary repository of Intrinsically Disordered Proteins (IDPs). This database is manually curated and the annotations there have strong experimental support. Currently, DisProt contains a relatively small number of proteins highlighting the importance of transferring annotations regarding verified disorder state and corresponding functions to homologous proteins in other species. In such a way, providing them with highly valuable information to better understand their biological roles. While the principles and practicalities of homology transfer are well-established for globular proteins, these are largely lacking for disordered proteins. We used DisProt to evaluate the transferability of the annotation terms to orthologous proteins. For each protein, we looked for their ort

SUBMITTER: Martinez-Perez E 

PROVIDER: S-EPMC10278204 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature