Effect of motion, cortical orientation and spatial resolution on quantitative imaging of cortical R₂* and magnetic susceptibility at 0.3 mm in-plane resolution at 7 T.

ABSTRACT: MR images of the effective relaxation rate R₂* and magnetic susceptibility χ derived from multi-echo T₂*-weighted (T₂*w) MRI can provide insight into iron and myelin distributions in the brain, with the potential of providing biomarkers for neurological disorders. Quantification of R₂* and χ at submillimeter resolution in the cortex in vivo has been difficult because of challenges such as head motion, limited signal to noise ratio, long scan time, and motion related magnetic field fluctuations. This work aimed to improve the robustness for quantifying intracortical R₂* and χ and analyze the effects from motion, spatial resolution, and cortical orientation. T₂*w data was acquired with a spatial resolution of 0.3 × 0.3 × 0.4 m

SUBMITTER: van Gelderen P 

PROVIDER: S-EPMC10278242 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature