Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.

ABSTRACT:

Background

Preclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects and clinical trials are ongoing to assess its impact on major clinical outcomes in patients with ARDS. However, the underlying mechanisms of these potential benefits are largely unknown. This investigation focused on the effects of sevoflurane on lung permeability changes after sterile injury and the possible associated mechanisms.

Methods

To investigate whether sevoflurane could decrease lung alveolar epithelial permeability through the Ras homolog family member A (RhoA)/phospho-Myosin Light Chain 2 (Ser19) (pMLC)/filamentous (F)-actin pathway and whether the receptor for advanced glycation end-products (RAGE) may mediate thes

SUBMITTER: Zhai R 

PROVIDER: S-EPMC10278282 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature