Use of novel structural features to identify urinary biomarkers during acute kidney injury that predict progression to chronic kidney disease.

ABSTRACT:

Background

A significant barrier to biomarker development in the field of acute kidney injury (AKI) is the use of kidney function to identify candidates. Progress in imaging technology makes it possible to detect early structural changes prior to a decline in kidney function. Early identification of those who will advance to chronic kidney disease (CKD) would allow for the initiation of interventions to halt progression. The goal of this study was to use a structural phenotype defined by magnetic resonance imaging and histology to advance biomarker discovery during the transition from AKI to CKD.

Methods

Urine was collected and analyzed from adult C57Bl/6 male mice at four days and 12 weeks after folic acid-induced AKI. Mice were euthanized 12 weeks after AKI and structural

SUBMITTER: Charlton JR 

PROVIDER: S-EPMC10278294 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature