Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is often accompanied by increased oxidative stress levels; however, it is still unclear whether PCOS itself is causally related to oxidative stress (OS), whether OS can increase the occurrence of PCOS, and which characteristics of PCOS increase OS levels. Therefore, this study explored the causal relationship between PCOS, its characteristics, and OS.

Methods

Two-sample bidirectional and two-sample Mendelian randomisation studies were performed based on publicly available statistics from genome-wide association studies. PCOS; its characteristics, such as testosterone, low-density lipoprotein, high-density lipoprotein; and 11 major OS markers (superoxide dismutase, glutathione S-transferase, glutathione peroxidase, catalase, uric ac

SUBMITTER: Yifu P 

PROVIDER: S-EPMC10278295 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature