Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.

ABSTRACT:

Background

Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth. However, the underlying mechanism of whether local GHR acts as a control valve to regulate mitochondrial function through mitochondrial biogenesis during myoblast differentiation remains unknown.

Methods

We manipulated the GHR expression in chicken primary myoblast to investigate its roles in mitochondrial biogenesis and function during myoblast differentiation.

Results

We reported that GHR is induced during myoblast differentiation. Local GHR promoted mitochondrial biogenesis during myoblast differentiation, as determined by th

SUBMITTER: Hu B 

PROVIDER: S-EPMC10278349 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature