PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment.

ABSTRACT:

Background

As a nucleolar protein associated with ribosome biogenesis in multiple cancer types, PES1 has been reported to be overexpressed, promoting cancer cell proliferation and invasion. However, in head and neck squamous cell carcinoma (HNSCC), the role of PES1 on the prognosis and immune infiltration remains unknown.

Methods

Multiple databases and qRT-PCR evaluated the expression of PES1 in HNSCC. The prognostic potential of PES1 in HNSCC patients was analyzed by Cox regression and Kaplan-Meier curves. Then, we used LASSO regression and stepwise multivariate Cox regression to construct the PES1-related risk assessment model. In addition, the association between PES1 and tumor immune microenvironment and drug sensitivity was explored by R packages. Finally, we used cell

SUBMITTER: He Y 

PROVIDER: S-EPMC10278488 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature