Hepatic disease control in patients with intrahepatic cholangiocarcinoma correlates with overall survival.

ABSTRACT:

Purpose

The role of locoregional therapy compared to systemic chemotherapy (SYS) for unresectable intrahepatic cholangiocarcinoma (IHC) remains controversial. The importance of hepatic disease control, either as initial or salvage therapy, is also unclear. We compared overall survival (OS) in patients treated with resection, hepatic arterial infusion pump (HAIP) chemotherapy, or SYS as it relates to hepatic recurrence or progression. We also evaluated recurrence after resection to determine the efficacy of locoregional salvage therapy.

Patients and methods

In this single-institution retrospective analysis, patients with biopsy-proven IHC treated with either curative-intent resection, HAIP (with or without SYS), or SYS alone were analyzed. Propensity score matching (PSM) was

SUBMITTER: Soares KC 

PROVIDER: S-EPMC10278501 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature