Prognostic assessment in patients operated for brain metastasis from systemic tumors.

ABSTRACT:

Background

Established models for prognostic assessment in patients with brain metastasis do not stratify for prior surgery. Here we tested the prognostic accuracy of the Graded Prognostic Assessment (GPA) score model in patients operated for BM and explored further prognostic factors.

Methods

We included 285 patients operated for brain metastasis at the University Hospital Zurich in the analysis. Information on patient characteristics, imaging, staging, peri- and postoperative complications and survival were extracted from the files and integrated into a multivariate Cox hazard model.

Results

The GPA score showed an association with outcome. We further identified residual tumor after surgery (p = 0.007, hazard ratio (HR) 1.6, 95% confidence interval (CI) 1.1-2.3) ste

SUBMITTER: Grossenbacher B 

PROVIDER: S-EPMC10278502 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature