Pure and mixed clear cell carcinoma of the endometrium: A molecular and immunohistochemical analysis study.

ABSTRACT:

Background

Uterine clear cell carcinoma (CCC) consists of either pure clear cell histology but can also display other histological components (mixed uterine CCCs). In this study, the molecular and immunohistochemical background of pure and mixed uterine CCC was compared. Secondly, it was evaluated whether histological classification and molecular background affected clinical outcome.

Methods

A retrospective multicenter study was performed comparing pure uterine CCCs (n = 22) and mixed uterine CCCs (n = 21). Targeted next-generation sequencing using a 12-gene targeted panel classified cases as polymerase-ε (POLE) mutated, microsatellite instable (MSI), TP53 wildtype or TP53 mutated. Immunohistochemistry was performed for estrogen receptor, progesterone receptor, L1 cell adhes

SUBMITTER: Reijnen C 

PROVIDER: S-EPMC10278528 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature