The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population.

ABSTRACT:

Background

Solute carrier family 22 member 3 (SLC22A3) gene had been reported to be associated with the efficacy of metformin in type 2 diabetes mellitus (T2DM). However, few studies reported the relationship between SLC22A3 polymorphism and T2DM. The aim of this study was to investigate the association of SLC22A3 polymorphism and susceptibility to T2DM in Chinese population.

Methods

We identified SLC22A3 rs555754, rs3123636, rs3088442 genotypes of 450 T2DM patients and 220 healthy controls from the Chinese population. The association between SNPs of SLC22A3 and susceptibility of T2DM was evaluated.

Results

The clinical characteristics were significantly different between T2DM patients and healthy controls. The polymorphisms of SL

SUBMITTER: Li Z 

PROVIDER: S-EPMC10278656 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature