Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention.

ABSTRACT:

Purpose

Frailty is a syndrome of vulnerability and physical decline with aging that increases risk for disability, hospitalizations, and death. To date, interventions for frailty have primarily focused on exercise and/or nutritional interventions, many of which show improvement in frailty-related characteristics, such as gait speed and lower extremity strength and function. The goal of this article was to review prior research studies investigating interventions for frailty and review the literature with regard to the role of insulin resistance and inflammation in the development of frailty. Also included is a discussion of potential therapeutic interventions for frailty.

Methods

A literature search was conducted by using PubMed and the search terms frailty, interventions, a

SUBMITTER: Espinoza SE 

PROVIDER: S-EPMC10279480 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature