Sex-specific associations between plasma interleukin-6 and depression in persons with and without HIV.

ABSTRACT:

Background

Persons with HIV (PWH) have both more frequent depression and higher levels of plasma inflammatory biomarkers compared to persons without HIV (PWoH). Inflammation and depressive symptoms are linked, including in PWH; however, it is unclear whether these associations differ by HIV serostatus and biological sex.

Methods

Six plasma inflammatory biomarkers were assessed using samples from PWH and PWoH who participated in six NIH-funded studies through the UCSD HIV Neurobehavioral Research Program (HNRP) from 2011 to 2019. Factor analysis was performed to identify intercorrelated groups of biomarkers. Factors and their components were then examined for relationships with Beck Depression Inventory-II (BDI-II) and modifying effects of sex or HIV serostatus using multivar

SUBMITTER: Petersen KJ 

PROVIDER: S-EPMC10279778 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature