Combining robust urine biomarkers to assess chronic kidney disease progression.

ABSTRACT:

Background

Urinary biomarkers may improve the prediction of chronic kidney disease (CKD) progression. Yet, data reporting the applicability of most commercial biomarker assays to the detection of their target analyte in urine together with an evaluation of their predictive performance are scarce.

Methods

30 commercial assays (ELISA) were tested for their ability to quantify the target analyte in urine using strict (FDA-approved) validation criteria. In an exploratory analysis, LASSO (Least Absolute Shrinkage and Selection Operator) logistic regression analysis was used to identify potentially complementary biomarkers predicting fast CKD progression, determined as the ⁵¹CrEDTA clearance-based measured glomerular filtration rate (mGFR) decline (>10% per year) in a s

SUBMITTER: Bienaime F 

PROVIDER: S-EPMC10279781 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature