Inherent differences of small airway contraction and Ca²⁺ oscillations in airway smooth muscle cells between BALB/c and C57BL/6 mouse strains.

ABSTRACT: BALB/c and C57BL/6 mouse strains are widely used as animal model in studies of respiratory diseases, such as asthma. Asthma is characterized by airway hyperresponsiveness, which is eventually resulted from the excessive airway smooth muscle (ASM) contraction mediated by Ca²⁺ oscillations in ASM cells. It is reported that BALB/c mice have inherently higher airway responsiveness, but show no different contractive response of tracheal ring as compared to C57BL/6 mice. However, whether the different airway responsiveness is due to the different extents of small airway contraction, and what's underlying mechanism remains unknown. Here, we assess agonist-induced small airway contraction and Ca²⁺ oscillations in ASM cells between BALB/c and C57BL/6 mice by using precision-cu

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC10279852 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature