Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice.

ABSTRACT: The relationship between intestinal microbiota and cognitive function has been investigated as one of the major topics within the intestinal microbiota-gut-brain axis. Although an increasing number of studies have demonstrated an improvement in learning and memory when using probiotics or prebiotics, to date, there are no studies that target the cognitive flexibility observed in the early stages of several neuropsychiatric diseases, including dementia. We have recently developed a novel behavioral task using the touchscreen operant system to assess cognitive flexibility. We found that the disruption of the intestinal microbiota in mice induced a decline in cognitive flexibility. In the present study, we investigated the effects of treatments consisting of Bifidobacterium animalis su

SUBMITTER: Ikuta K 

PROVIDER: S-EPMC10279864 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature