GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma.

ABSTRACT:

Background

Asthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen species (ROS), play a major role. Superoxide dismutases (SODs) are enzymes that constitute the first line of defense against ROS. Melon SOD-gliadin, which is known as GliSODin®, is commonly used as a nutritional supplement that has proven antioxidant properties.

Objectives

In this study, we evaluated the efficacy and mechanism of action GliSODin® in the treatment of allergic asthma.

Methods

House dust mite (HDM)-induced asthmatic mice were orally exposed to GliSODin®, and airway hyperresponsiveness, lung inflammation,

SUBMITTER: Klein M 

PROVIDER: S-EPMC10279865 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature