Pathogenic role of S100 proteins in psoriasis.

ABSTRACT: Psoriasis is a chronic inflammatory skin disease. The histopathological features of psoriasis include excessive proliferation of keratinocytes and infiltration of immune cells. The S100 proteins are a group of EF-hand Ca²⁺-binding proteins, including S100A2, -A7, -A8/A9, -A12, -A15, which expression levels are markedly upregulated in psoriatic skin. These proteins exert numerous functions such as serving as intracellular Ca²⁺ sensors, transduction of Ca²⁺ signaling, response to extracellular stimuli, energy metabolism, and regulating cell proliferation and apoptosis. Evidence shows a crucial role of S100 proteins in the development and progress of inflammatory diseases, including psoriasis. S100 proteins can possibly be used as potential therapeutic target

SUBMITTER: Liang H 

PROVIDER: S-EPMC10279876 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature