A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer.

ABSTRACT:

Background

Prostate cancer is the most heritable cancer. There is a need to identify possible modifiable factors for men at an increased risk of prostate cancer due to genetic factors.

Objective

To examine whether men at an increased genetic risk of prostate cancer can offset their risk of disease or disease progression by adhering to a healthy lifestyle.

Design, setting, and participants

We prospectively followed 12 411 genotyped men in the Health Professionals Follow-up Study (1993-2019) and the Physicians' Health Study (1983-2010). Genetic risk of prostate cancer was quantified using a polygenic risk score (PRS). A healthy lifestyle was defined by healthy weight, vigorous physical activity, not smoking, and a healthy diet.

Outcome measurements and statistical an

SUBMITTER: Plym A 

PROVIDER: S-EPMC10279925 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature