Influence of Rho/ROCK inhibitor Y-27632 on proliferation of equine mesenchymal stromal cells.

ABSTRACT: Mesenchymal stromal cells (MSC) isolated form bone marrow and adipose tissue are the most common cells used for cell therapy of orthopedic diseases. MSC derived from different tissues show differences in terms of their proliferation, differentiation potential and viability in prolonged cell culture. This suggests that there may be subtle differences in intracellular signaling pathways that modulate these cellular characteristics. The Rho/ROCK signaling pathway is essential for many cellular functions. Targeting of this pathway by the ROCK inhibitor Y-27632 has been shown to be beneficial for cell viability and proliferation of different cell types. The aim of this study was to investigate the effects of Rho/ROCK inhibition on equine MSC proliferation using bone marrow-derived MSC (BMSC) an

SUBMITTER: Melzer M 

PROVIDER: S-EPMC10279950 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature