Subtype and prognostic analysis of immunogenic cell death-related gene signature in prostate cancer.

ABSTRACT:

Background

Immunogenic cell death (ICD) plays a vital role in tumor progression and immune response. However, the integrative role of ICD-related genes and subtypes in the tumor microenvironment (TME) in prostate cancer (PCa) remains unknown.

Materials and methods

The sample data were obtained from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Memorial Sloan Kettering Cancer Center (MSKCC) prostate cancer-related databases. We first divided the subtypes based on ICD genes from 901 PCa patients and then identified the prognosis- related genes (PRGs) between different ICD subtypes. Subsequently, all the patients were randomly split into the training and test groups. We developed a risk signature in the training set by least absolute shrinkage and selection

SUBMITTER: Kang Z 

PROVIDER: S-EPMC10279955 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature