New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK inhibition.

ABSTRACT: In vitro anticancer screening of Silene succulenta Forssk. aerial parts (Caryophyllaceae) showed that the n-hexane fraction was a highly effective fraction against breast carcinoma cell lines (MCF-7) with IC₅₀ = 15.5 μg mL^-1. The bioactive-guided approach led to the isolation of two new cyclic glucolipids from the n-hexane fraction, identified as a 1,2'-cyclic ester of 11-oxy-(6'-O-acetyl-β-d-glucopyranosyl) behenic acid (1) as a C-11 epimeric mixture and 11(R)-oxy-(β-d-glucopyranosyl)-1,2'-cyclic ester of behenic acid (2). An in vitro cytotoxicity study showed the potential suppression of MCF-7 cells with IC₅₀ values of 11.7 ± 0.04 and 6.6 ± 0.01 μg mL^-1 for compounds 1 and 2, respectively, compar

SUBMITTER: Badawy SA 

PROVIDER: S-EPMC10280128 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature