Proangiogenic role of circRNA-007371 in liver fibrosis.

ABSTRACT: Circular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs in liver fibrosis remain unknown and are the focus of this study. Murine fibrotic models were induced by thioacetamide (TAA) or carbon tetrachloride (CCl₄ ). Increased angiogenesis is accompanied by liver fibrosis in TAA- and CCl₄ -induced murine fibrotic livers. circRNA microarray and argonaute 2 (AGO2)-RNA immunoprecipitation (RIP) sequencing (AGO2-RIP sequencing) were performed in murine livers to screen for functional circRNAs. Compared to control livers, 86 differentially expressed circRNAs were obtained in TAA-induced murine fibrotic livers using circRNA microarray. In addition, 551 circRNAs w

SUBMITTER: Zhao C 

PROVIDER: S-EPMC10280135 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature