Inhibition of hepatitis B virus activities by Rhazya stricta‑derived acacetin and acetyl‑β‑carboline.

ABSTRACT: Hepatitis B virus (HBV) causes acute and chronic liver diseases, leading to cirrhosis and hepatocellular carcinoma. Although direct-acting nucleoside analogs, such as lamivudine (LAM), adefovir and famciclovir, are available, emergence of drug-resistance due to mutations in HBV polymerase (POL) restricts their further use. Alternatively, numerous plant products and compounds isolated from plants have been reported to confer anti-HBV efficacies without any sign of resistance in vitro or in vivo. As, flavonoids and alkaloids are the most widely reported antivirals, the anti-HBV activities of the flavonoid acacetin (ACT) and the alkaloid acetyl-β-carboline (ABC) from the aerial parts of Rhazya stricta were assessed in the present study. Both compounds were isolated from t

SUBMITTER: Parvez MK 

PROVIDER: S-EPMC10280320 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature