Fast ¹⁹F Magic-Angle Spinning Nuclear Magnetic Resonance for the Structural Characterization of Active Pharmaceutical Ingredients in Blockbuster Drugs.

ABSTRACT: Fluorinated drugs occupy a large and growing share of the pharmaceutical market. Here, we explore high-frequency, 60 to 111 kHz, ¹⁹F magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy for the structural characterization of fluorinated active pharmaceutical ingredients in commercial formulations of seven blockbuster drugs: Celebrex, Cipro, Crestor, Levaquin, Lipitor, Prozac, and Zyvox. ¹⁹F signals can be observed in a single scan, and spectra with high signal-to-noise ratios can be acquired in minutes. ¹⁹F spectral parameters, such as chemical shifts and line widths, are sensitive to both the nature of the fluorine moiety and the formulation. We anticipate that the fast ¹⁹F MAS NMR-based approach presented here will be valuab

SUBMITTER: Quinn CM 

PROVIDER: S-EPMC10280463 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature