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Essential role of bromodomain proteins in renal cell carcinoma (Review).

ABSTRACT: Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on bromodomain family proteins in RCC are limited and the roles of bromodomain family proteins in RCC have remained to be fully elucidated. The present review discussed the role of bromodomain family proteins in RCC, aiming to explore possible potential therapeutic targets of BRD‑related drugs in this type of cancer.

SUBMITTER: Wen Q

PROVIDER: S-EPMC10280547 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Essential role of bromodomain proteins in renal cell carcinoma (Review).

Wen Qianghai Q Liu Haicheng H Lou Kecheng K Zhang Xing X Chao Wei W Xin Jianhui J Gong Jiaxiang J Zou Junrong J Zou Xiaofeng X

Molecular medicine reports 20230609 1

Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on ...[more]

PMID: 37293842

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