Role of pancreatic ductal adenocarcinoma risk factors in intraductal papillary mucinous neoplasm progression.

ABSTRACT:

Introduction

Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis and lack of successful treatments. A possible strategy to reduce its death burden is prevention. Intraductal papillary mucinous neoplasms (IPMNs) are precursors of PDAC. It is difficult to estimate the incidence of IPMNs because they are asymptomatic. Two recent studies reported pancreatic cysts in 3% and 13% of scanned subjects. The possibility of identifying a subgroup of IPMN patients with a higher probability of progression into cancer could be instrumental in increasing the survival rate. In this study, genetic and non-genetic PDAC risk factors were tested in a group of IPMN patients under surveillance.

Methods

A retrospective study was conducted on 354 IPMN patients enrolled in two

SUBMITTER: Gentiluomo M 

PROVIDER: S-EPMC10280811 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature