Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA.

ABSTRACT:

Background

Bone defects remain a challenge today. In addition to osteogenic activation, the crucial role of angiogenesis has also gained attention. In particular, vascular endothelial growth factor (VEGF) is likely to play a significant role in bone regeneration, not only to restore blood supply but also to be directly involved in the osteogenic differentiation of mesenchymal stem cells. In this study, to produce additive angiogenic-osteogenic effects in the process of bone regeneration, VEGF and Runt-related transcription factor 2 (Runx2), an essential transcription factor for osteogenic differentiation, were coadministered with messenger RNAs (mRNAs) to bone defects in the rat mandible.

Methods

The mRNAs encoding VEGF or Runx2 were prepared via in vitro transcription (IVT)

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10280834 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature