Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2.

ABSTRACT:

Background

In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing evidence has shown that the external microenvironmental factors also play a crucial role in restoring the survival of RGCs by promoting the regrowth of RGC axons, especially inflammatory factors. In this study, we aimed to screen out the underlying inflammatory factor involved in the signaling of staurosporine (STS)-induced axon regeneration and verify its role in the protection of RGCs and the promotion of axon regrowth.

Methods

We performed transcriptome RNA sequencing for STS induction models in vitro and analyzed the differentially expressed genes. After targeting the key gene, we verified t

SUBMITTER: Zhang ZY 

PROVIDER: S-EPMC10280836 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature