Primary non-response to antiviral therapy affects the prognosis of hepatitis B virus-related hepatocellular carcinoma

ABSTRACT:

Background and aim

Although antiviral treatments have been shown to affect the recurrence and long-term survival of patients with hepatocellular carcinoma (HCC) who have high viral loads, the effect of different responses to antiviral therapy on the clinical outcomes remains unclear. This study aimed to assess the effect of primary non-response (no-PR) to antiviral therapy on the survival or prognosis of patients with HCC with a high load of hepatitis B virus (HBV) DNA.

Methods

A total of 493 HBV-HCC patients hospitalized at Beijing Ditan Hospital of Capital Medical University were admitted to this retrospective study. Patients were divided into two groups based on viral response (no-PR and primary response). Kaplan–Meier (KM) curves were used to compare the overall survi

SUBMITTER: Wang P 

PROVIDER: S-EPMC10280839 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature