Sex specific molecular networks and key drivers of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is a progressive and age-associated neurodegenerative disorder that affects women disproportionally. However, the underlying mechanisms are poorly characterized. Moreover, while the interplay between sex and ApoE genotype in AD has been investigated, multi-omics studies to understand this interaction are limited. Therefore, we applied systems biology approaches to investigate sex-specific molecular networks of AD.

Methods

We integrated large-scale human postmortem brain transcriptomic data of AD from two cohorts (MSBB and ROSMAP) via multiscale network analysis and identified key drivers with sexually dimorphic expression patterns and/or different responses to APOE genotypes between sexes. The expression patterns and functional relevance o

SUBMITTER: Guo L 

PROVIDER: S-EPMC10280841 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature