Panax notoginseng alleviates oxidative stress through miRNA regulations based on systems biology approach.

ABSTRACT:

Background

Herbal medicine Sanqi (SQ), the dried root or stem of Panax notoginseng (PNS), has been reported to have anti-diabetic and anti-obesity effects and is usually administered as a decoction for Chinese medicine. Alternative to utilizing PNS pure compound for treatment, we are motivated to propose an unconventional scheme to investigate the functions of PNS mixture. However, studies providing a detailed overview of the transcriptomics-based signaling network in response to PNS are seldom available.

Methods

To explore the reasoning of PNS in treating metabolic disorders such as insulin resistance, we implemented a systems biology-based approach with RNA sequencing (RNA-seq) and miRNA sequencing data to elucidate key pathways, genes and miRNAs involved.

Results

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SUBMITTER: Tang Y 

PROVIDER: S-EPMC10280844 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature