Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats.

ABSTRACT:

Background

Though titanium dioxide (TiO₂) is generally considered to have a low impact in the human body, the safety of TiO₂ containing nanosized particles (NPs) has attracted attention. We found that the toxicity of silver NPs markedly varied depending on their particle size, as silver NPs with a diameter of 10 nm exhibited fatal toxicity in female BALB/c mice, unlike those with diameters of 60 and 100 nm. Therefore, the toxicological effects of the smallest available TiO₂ NPs with a crystallite size of 6 nm were examined in male and female F344/DuCrlCrlj rats by repeated oral administration of 10, 100, and 1000 mg/kg bw/day (5/sex/group) for 28 days and of 100, 300, and 1000 mg/kg bw/day (10/sex/group) for 90 days.

Results

In both 28- and 9

SUBMITTER: Akagi JI 

PROVIDER: S-EPMC10280982 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature