Galectin-3 is Associated with Heart Failure Incidence: A Meta-Analysis.

ABSTRACT:

Introduction

Heart failure (HF) is a leading cause of death worldwide. The global prevalence of heart failure is projected to increase rapidly in the coming decades, and significant attention has turned to improving biomarker-based risk prediction of incident HF. This paper aimed to qualitatively and quantitatively evaluate the evidence associating levels of galectin-3 with the risk of incident HF.

Methods

A review of PUBMED-indexed peer-reviewed literature was performed. Nine studies met the inclusion criteria, and all nine had data eligible for conversion and pooling. A randomeffects meta-analysis was performed using hazard ratios and 95% confidence intervals from a minimally adjusted model, a further adjusted model, and from subgroups within the further-adjusted model.

SUBMITTER: Baccouche BM 

PROVIDER: S-EPMC10280995 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature