Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance.

ABSTRACT: Germline transmission of epigenetic information is a critical component of epigenetic inheritance. Previous studies have suggested that an erasure of DNA methylation is required to develop stem cells in the morula embryo. An exception involves imprinted genes that escape this DNA methylation erasure. Transgenerational differential DNA methylation regions (DMRs) have been speculated to be imprinted-like and escape this erasure. The current study was designed to assess if morula embryos escape the erasure of dichlorodiphenyltrichloroethane-induced transgenerational sperm DMR methylation. Observations demonstrate that the majority (98%) of transgenerational sperm DMR sites retain DNA methylation and are not erased, so appearing similar to imprinted-like sites. Interestingly, observations also

SUBMITTER: Ben Maamar M 

PROVIDER: S-EPMC10281242 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature