Altered gut microbiota in older adults with mild cognitive impairment: a case-control study.

ABSTRACT:

Introduction

The microbiota-gut-brain axis is implicated in Alzheimer's disease. Gut microbiota alterations in mild cognitive impairment (MCI) are inconsistent and remain to be understood. This study aims to investigate the gut microbial composition associated with MCI, cognitive functions, and structural brain differences.

Methods

A nested case-control study was conducted in a community-based prospective cohort where detailed cognitive functions and structural brain images were collected. Thirty-one individuals with MCI were matched to sixty-five cognitively normal controls by age strata, gender, and urban/rural area. Fecal samples were examined using 16S ribosomal RNA (rRNA) V3-V4 sequencing. Compositional differences between the two groups were identified and correlated w

SUBMITTER: Fan KC 

PROVIDER: S-EPMC10281289 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature