Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017-2018.

ABSTRACT: Multiple animals and in vitro studies have demonstrated that perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure causes liver damage associated with fat metabolism. However, it is lack of population evidence for the correlation between PFAS exposure and nonalcoholic fatty liver disease (NAFLD). A cross-sectional analysis was performed of 1150 participants aged over 20 from the US. Liver ultrasound transient elastography was to identify the participants with NAFLD and multiple biomarkers were the indicators for hepatic steatosis and hepatic fibrosis. Logistics regression and restricted cubic splines models were used to estimate the association between PFASs and NAFLD. PFASs had not a significant association with NAFLD after adjustment. The hepatic steatosis indicators incl

SUBMITTER: Cheng W 

PROVIDER: S-EPMC10281433 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature