Intra-articular injection of flavopiridol-loaded microparticles for treatment of post-traumatic osteoarthritis.

ABSTRACT: Rapid joint clearance of small molecule drugs is the major limitation of current clinical approaches to osteoarthritis and its subtypes, including post-traumatic osteoarthritis (PTOA). Particulate systems such as nano/microtechnology could provide a potential avenue for improved joint retention of small molecule drugs. One drug of interest for PTOA treatment is flavopiridol, which inhibits cyclin-dependent kinase 9 (CDK9). Herein, polylactide-co-glycolide microparticles encapsulating flavopiridol were formulated, characterized, and evaluated as a strategy to mitigate PTOA-associated inflammation through the inhibition of CDK9. Characterization of the microparticles, including the drug loading, hydrodynamic diameter, stability, and release profile was performed. The mean hydrodynamic diamet

SUBMITTER: Sangsuwan R 

PROVIDER: S-EPMC10281459 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature