In silico and in vivo demonstration of the regulatory mechanism of Qi-Ge decoction in treating NAFLD.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD), a chronic and progressive liver disease, often causes steatosis and steatohepatitis. Qi-Ge decoction (QGD) shows a good effect against NAFLD in the clinic. But the molecular mechanism for QGD in improving NAFLD is unknown.

Purpose

This study explored the molecular mechanism of QGD in NAFLD model rats using comprehensive network pharmacology, molecular docking and in vivo verification strategies.

Methods

Active components and targets of QGD were obtained from public database. The overlapped genes between QGD and NAFLD targets were analyzed by enrichment analysis. Active components and targets were used to predict molecular docking analysis. Finally, seven key targets were screened out and the gene expression w

SUBMITTER: Peng C 

PROVIDER: S-EPMC10281479 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature