Trial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment.

ABSTRACT: Photodynamic therapy (PDT) is a medical treatment used to target solid tumors, where the administration of a photosensitizing agent and light generate reactive oxygen species (ROS), thus resulting in strong oxidative stress that selectively damages the illuminated tissues. Several preclinical studies have demonstrated that PDT can prime the immune system to recognize and attack cancer cells throughout the body. However, there is still limited evidence of PDT-mediated anti-tumor immunity in clinical settings. In the last decade, several clinical trials on PDT for cancer treatment have been initiated, indicating that significant efforts are being made to improve current PDT protocols. However, most of these studies disregarded the immunological dimension of PDT. The immunomodulatory properti

SUBMITTER: Penetra M 

PROVIDER: S-EPMC10281486 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature