Proteomic cardiovascular risk assessment in chronic kidney disease.

ABSTRACT:

Aims

Chronic kidney disease (CKD) is widely prevalent and independently increases cardiovascular risk. Cardiovascular risk prediction tools derived in the general population perform poorly in CKD. Through large-scale proteomics discovery, this study aimed to create more accurate cardiovascular risk models.

Methods and results

Elastic net regression was used to derive a proteomic risk model for incident cardiovascular risk in 2182 participants from the Chronic Renal Insufficiency Cohort. The model was then validated in 485 participants from the Atherosclerosis Risk in Communities cohort. All participants had CKD and no history of cardiovascular disease at study baseline when ∼5000 proteins were measured. The proteomic risk model, which consisted of 32 proteins, was superior t

SUBMITTER: Deo R 

PROVIDER: S-EPMC10281556 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature