Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries.

ABSTRACT:

Background

Klebsiella pneumoniae is the most common pathogen causing neonatal infections, leading to high mortality worldwide. Along with increasing antimicrobial use in neonates, carbapenem-resistant K. pneumoniae (CRKP) has emerged as a severe challenge for infection control and treatment. However, no comprehensive systematic review is available to describe the global epidemiology of neonatal CRKP infections. We therefore performed a systematic review of available data worldwide and combined a genome-based analysis to address the prevalence, clonal diversity, and carbapenem resistance genes of CRKP causing neonatal infections.

Methods and findings

We performed a systematic review of studies reporting population-based neonatal infections caused by CRKP in combination with a

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10281588 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature