Real-time functional magnetic resonance imaging neurofeedback training of amygdala upregulation increases affective flexibility in depression.

ABSTRACT:

Background

Decreased affective flexibility is associated with depression symptoms, and it has been suggested that common interventions may target this mechanism. To explore this hypothesis, we evaluated whether real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala responses during positive memory recall resulted in both symptom improvements, as has been observed previously, and flexibility to decrease amygdala reactivity in response to a cognitive task among patients with major depressive disorder (MDD).

Methods

In a double-blind, placebo-controlled, randomized clinical trial, adults with MDD received 2 sessions of rtfMRI-nf training to increase their amygdala (experimental group) or parietal (control group) responses dur

SUBMITTER: Compere L 

PROVIDER: S-EPMC10281719 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature