Neural signature of mobility-related everyday function in older adults at-risk of cognitive impairment.

ABSTRACT: Assessment of everyday activities is central to the diagnosis of dementia. Yet, little is known about brain processes associated with everyday functional limitations, particularly during early stages of cognitive decline. Twenty-six older adults (mean = 74.9 y) were stratified by risk using the Montreal Cognitive Assessment battery (MoCA, range: 0- 30) to classify individuals as higher (22-26) and lower risk (27+) of cognitive impairment. We investigated everyday function using a gait task designed to destabilize posture and applied Mobile Brain/Body Imaging. We predicted that participants would increase step width to gain stability, yet the underlying neural signatures would be different for lower versus higher risk individuals. Step width and fronto-parietal activation increased during v

SUBMITTER: De Sanctis P 

PROVIDER: S-EPMC10281759 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature