CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer.

ABSTRACT: As one of the most essential components of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) interact extensively with cancer cells and other stromal cells to remodel TME and participate in the pathogenesis of cancer, which earmarked themselves as new promising targets for cancer therapy. Numerous studies have highlighted the heterogeneity and versatility of CAFs in most cancer types. Thus, the identification and appropriate use of CAF-related genes (CAFGenes) in the context of specific cancer types will provide critical insights into disease mechanisms and CAF-related therapeutic targets. In this study, we collected and curated 5421 CAFGenes identified from small- or large-scale experiments, encompassing 4982 responsors that directly or indirectly participate in cance

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC10281871 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature