Molecular function of Kruppel-like factor 7 in biology.

ABSTRACT: Krüppel-like factor 7 ( KLF7), also named ubiquitous KLF ( UKLF) based on its ubiquitous expression in adult human tissues, is a conserved gene in animals. There are few reports on KLF7 among KLFs; however, an increasing number of reports are demonstrating that KLF7 plays an important role in development and diseases. Genetic studies have shown that the DNA polymorphisms of KLF7 are associated with obesity, type 2 diabetes mellitus (T2DM), lachrymal/salivary gland lesions, and mental development in some populations of humans, and the DNA methylation of KLF7 is associated with the development of diffuse gastric cancer. In addition, biological function studies have shown that KLF7 regulates the development of the nervous system, adipose tissue, muscle tissu

SUBMITTER: Mao Y 

PROVIDER: S-EPMC10281879 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature