Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test.

ABSTRACT: The forced swim test (FST) is widely used to screen for potential antidepressant drugs and treatments. Despite this, the nature of stillness during FST and whether it resembles "depressive-like behavior" are widely debated issues. Furthermore, despite being widely used as a behavioral assay, the effects of the FST on the brain transcriptome are rarely investigated. Therefore, in this study we have investigated changes in the transcriptome of the rat hippocampus 20 min and 24 h after FST exposure. RNA-Seq is performed on the hippocampus tissues of rats 20 min and 24 h after an FST. Differentially expressed genes (DEGs) were identified using limma and used to construct gene interaction networks. Fourteen differentially expressed genes (DEGs) were identified only in the 20-m group. No DEGs we

SUBMITTER: Vlasov I 

PROVIDER: S-EPMC10281975 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature