Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia.

ABSTRACT: Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread impairment of structural and functional integration has been demonstrated in schizophrenia. Although white matter (WM) microstructural abnormalities have been commonly reported in schizophrenia, the dysfunction of WM as well as the relationship between structure and function in WM remains uncertain. In this study, we proposed a novel structure-function coupling measurement to reflect neuronal information transfer, which combined spatial-temporal correlations of functional signals with diffusion tensor orientations in the WM circuit from functional and diffusion magnetic resonance images (MRI). By analyzing MRI data from 75 individuals with schizophrenia (SZ) and 89 healthy volunteers (HV), the associations b

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10281980 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature