Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors.

ABSTRACT: The gut microbiome is important for human health, yet modulation requires more insight into inter-individual variation. Here, we explored latent structures of the human gut microbiome across the human lifespan, applying partitioning, pseudotime, and ordination approaches to >35,000 samples. Specifically, three major gut microbiome branches were identified, within which multiple partitions were observed in adulthood, with differential abundances of species along branches. Different compositions and metabolic functions characterized the branches' tips, reflecting ecological differences. An unsupervised network analysis from longitudinal data from 745 individuals showed that partitions exhibited connected gut microbiome states rather than over-partitioning. Stability in the Bacteroides-enrich

SUBMITTER: Tap J 

PROVIDER: S-EPMC10282066 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature